All members of Darwin are encouraged to present their research at informal seminars held on Tuesdays and Thursdays during term. Everyone is welcome, whatever your degree or discipline.
Darwin members pick up lunch from 12:00, taking it into the Richard King Room (on the left at the top of the stairs leading to the dining hall) or 1 Newnham Terrace (straight through at the far end of the dining hall). Wine is served. Non-Darwin members are welcome to attend, although lunch is only available to guests of members. The talk begins at about 1:15 and lasts for about 20 minutes and is followed by questions over coffee. We adjourn at 2:00pm at the latest.
Homo sapiens has a global distribution, a remarkable achievement for a tropical ape. Adaptations enabling this colonisation are intriguing given suggestions that humans exhibits high levels of physiological and behavioural malleability associated with a ‘colonising niche’. Differences in body size/shape between members of the same species from different climates are well-known adaptations in mammals; could relatively flexible size/shape have been important to human species adapting to novel habitats? If so, at what point did this flexibility arise? To address these questions, a base-line for adaptation to climate must be established by comparison with suitable outgroups. Japanese macaques (Macaca fuscata) are the most northerly living non-human primates. They have great latitudinal spread and overlap with the historical distribution of prehistoric Jomon foragers, allowing matched latitude comparisons within monkeys and humans and making them an ideal outgroup for this study. We compare skeletons of M. fuscata from four different latitudes, including the most northerly and most southerly extremes of the species’ distribution. Initial results show inter-group differences in M. fuscata postcranial and cranial size and shape. Size varies more than shape, showing a strong, positive relationship with latitude. However, the very small size of the southern-most (island) sample may be affected by resource availability. Allometry-free shape shows geographic patterning and perhaps echoes some trends seen in human groups at high latitudes. These insights begin to provide a comparison for human adaptation to climatic diversity and the role of colonisation in shaping the evolution and dispersal of human species.
Buck, L. T.1, 2, De Groote, I.3, Hamada, Y.4, Stock, J. T.1
1 Department of Archaeology, University of Cambridge
2 Department of Earth Sciences, Natural History Museum
3 School of Natural Sciences and Psychology, Liverpool John Moores University
4 Section of Evolutionary Morphology, Primate Research Institute, Kyoto University
Funding: This work was supported by the European Research Council (ADaPt Project: FP7-IDEAS-ERC 617627).
The cost of modelling existing industrial facilities is currently considered to counteract the benefits
of the model in managing and retrofitting the facility. 90% of the modelling cost is typically spent
on labour for converting point cloud data to the final model, hence reducing the cost is only
possible by automating this step. Previous research has successfully validated methods for
modelling specific object types such as cylinders. Yet modelling is still prohibitively expensive.
During this talk, the most important object types of industrial facilities will be identified by ranking
them according to their frequency of appearance and the man-hours required for modelling in a
state of the art software, EdgeWise. This work is the first to rank objects according to their priority
for automated modelling. These are straight pipes, electrical conduit and circular hollow sections
and constitute more than 80 % of industrial plants on average. This is significant because state-ofthe-
art practice has achieved semi-automated cylinder detection saving 64 % of their manual
modelling time for the case studies investigated. Automated detection and semantic classification
methods for the recognition of the abovementioned objects will be analyzed.
The Anaphase promoting complex/ cyclosome (APC/C) is a 1.2 MDa multi-subunit E3 ubiquitin ligase that encodes broad substrate-specificity via its two co-activators Cdc20 and Cdh1 and three principal degrons: the D-box, KEN box and ABBA motif. The regulation of mitotic exit is tightly controlled by the expression and degradation of these two co-activators through stages of the cell cycle. The upregulation of Cdc20 is associated with many cancers including pancreatic, breast and cervical cancers and hepatocellular carcinomas. However, to date, no specific inhibitors of the APC/CCdc20 exist in the clinic. Only two APC/C specific compounds have been discovered: TAME/pro-TAME, which disrupts the C-terminal IR tail of Cdc20 binding to APC3, and Apcin, which disrupts substrate D-box degron binding to Cdc20. Recent studies have highlighted the need for a combination strategy to achieve full inhibition of the APC/CCdc20. We propose a new approach involving the design of constrained peptides to inhibit key oncogenic protein-protein interactions with the APC/CCdc20,for the treatment of a wide range of cancers.