Investigating human blood development at the single-cell level

Darwin College Sciences Group
Anna Maria Ranzoni - Wellcome - MRC Cambridge Stem Cell Institute/Wellcome Trust Sanger Institute
The Richard King Room, Darwin College
Thursday, December 5, 2019 - 13:10 to 14:00

Blood production during foetal development involves separate waves of
migration of rare stem cells among different organs, including aorta,
liver and bones. It is still unclear how human foetal blood stem cells
arise, expand and differentiate in the more than ten cell types that
carry out vital body functions such as carrying oxygen, clotting and
fighting infections. In my research, I utilise a variety of
technologies, including single-cell RNA sequencing, whole genome
sequencing and cell-culture assays, to characterise foetal blood
progenitors and to understand how stem cells colonise the different
organs during development. Uncovering the dynamics of blood production
in foetal development has both biological and translational
implications. Foetal stem cells have a higher regenerative potential
than their adult counterparts and studying them could provide important
insights on how we can mimic these properties in the production of blood
stem cells ex-vivo for regenerative medicine purposes.

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