Reported in Nature last week, one of the largest sets of high quality human induced pluripotent stem cell lines from healthy individuals has been produced by a consortium involving two Cambridge institutes, the Wellcome Trust Sanger Institute and the European Bioinformatics Institute. Study co-author, Darwin College Postdoctoral Affiliate Dr. Angela Goncalves, explains: “Each of the 711 stem cell lines generated has been extensively characterised. These cells are publicly available, as are all the phenotypic data generated about them, ranging from measurements of gene expression and protein abundances to information about cell morphology. Our study investigated the determinants of variation in the properties of iPSCs from person to person and found that common genetic variation played a much more important role than any experimental factors.”
Helena Kilpinen and Angela Goncalves et al. (2017) Common genetic variation drives molecular heterogeneity in human iPSCs. Nature. DOI: 10.1038/nature22403
What is a stem cell?